Vitamin C and Sepsis
Last Updated:
Fri Dec 28 10:19:09 EST 2018
"The potential to save millions of lives." – Paul Marik, MD
Hydrocortisone, Vitamin C and Thiamine (Vitamin B1) Reduce Vasopressor Need in SepsisDouble-blind, clinical study. Also read Early Thiamine supplementation reduces mortality in patients of septic shock
The Cure for Sepsis – Vitamin C, Hydrocortisone and vitamin B1
"Completely devoid of side effects.." (Vitamin C/Cortisol/Vitamin B1 treatment)
"the sepsis deaths in this country are equivalent to 3 jumbo jets crashing every single day.. Every single day.."
"In fact, more people die from sepsis than die from breast cancer, colon cancer and AIDS put together.."
"It's the most common cause of death in our hospitals and costs our country more than 20 Billion dollars.."
"Over a hundred randomized trials have been done with all kinds of pharmaceutical agents, and none have worked…"
"on top of 2000 studies looking at sepsis.."
"…we are vitamin C mutants.."
".. Nobody is going to make any money from this, but it has the potential of saving millions of lives.."
"..Millions of patients will die waiting for these trials.."
".. There is data to support using it right how…" (April 2017)
After Dr. Marik's Vitamin C Cures Sepsis discovery was shown on television it created a new standard of medical care. According to Dr. Levy,
It's all a question of when critical mass is reached, and I think the TV report pushed the issue to that point…" – r. Thomas E. Levy. MD, JD
The interesting aspect is that most doctors are not familiar with hydrocortisone, the bioidentical equivalent to our natural hormone cortisol. They are much more familiar with the drug-analogs, such as prednisone. But this Sepsis treatment specifically makes use of hydrocortisone. ER doctors, at least, have some learning to do.
Indeed, Marik, who remains a strong proponent of this approach, rejects the findings of the study. He tells NPR that by his reckoning, patients in the study received treatment far too late in the course of their disease. "It's like giving it to a patient who's dead," he says. "It's of no benefit. The horse was out of the barn miles beforehand."Marik, at Eastern Virginia Medical School, gives his patients the vitamin C infusion as quickly as he recognizes signs of sepsis. That's impossible to do in a study in which participants must be enrolled in a study and then randomized into one of the two comparison groups before treatment can begin.
"The question is, why does this study not replicate real-life experience and the experience of hundreds of clinicians around the world?" he asks.
Marik says in his experience, the treatment is only effective if given within six hours after someone has suspected sepsis. At the meeting in Belfast, Dr. Tomoko Fujii, on the study research team at Monash University, said they provided treatment an average of 12 hours after patients arrived in the intensive care unit. Patients came from a variety of locations, including the emergency room, and she said they have no information about how long they had been septic before arriving at the ICU.
Deathbed Scurvy By Bill Sardi
Early Vitamin C/Sepsis Research Ignored
Marik's invention of combining ascorbate (vitamin C) with cortisol (and then Thiamine, vitamin B1) is new and brilliant.
Current thinking is that the cortisol/hydrocortisone cell receptors become oxidized in sepsis. The purpose of the antioxidant vitamin C is to repair (reduce) these nonfunctional receptors.
June 2011: Sepsis: Leaking blood vessels may be cause of infection-spreading condition, researchers suggest
Sepsis kills about 1,400 people a day worldwide and is the second-leading cause of death in intensive care units in Canada. Despite intense research, the death rate remains high, between 30 and 50 per cent. Treatments largely consist of surgical removal or drainage of the infected site, antibiotics and supportive care.
"The lack of therapies is not for want of effort. On the basis of promising in vitro and animal studies, many drugs have entered clinical trials only to fail, resulting in the description of sepsis research as a 'graveyard' of discovery," said Dr. Lee, a critical care physician and researcher in the hospital's L Ka Shing Knowledge Institute.
October 2011: Vitamin C in Sepsis
Therefore, it may be possible to improve microvascular function in sepsis by using intravenous vitamin C as an adjunct therapy.
http://link.springer.com/chapter/10.1007%2F978-94-007-2199-9_5
December 2010: Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? (Foundation received copy of this Paper)
The history of ascorbic acid (AA) and cancer has been marked with controversy. Clinical studies evaluating AA in cancer outcome continue to the present day. However, the wealth of data suggesting that AA may be highly beneficial in addressing cancer-associated inflammation, particularly progression to systemic inflammatory response syndrome (SIRS) and multi organ failure (MOF), has been largely overlooked.
Patients with advanced cancer are generally deficient in AA. Once these patients develop septic symptoms, a further decrease in ascorbic acid levels occurs. Given the known role of ascorbate in: a) maintaining endothelial and suppression of inflammatory markers; b) protection from sepsis in animal models; and c) direct antineoplastic effects, we propose the use of ascorbate as an adjuvant to existing modalities in the treatment and prevention of cancer-associated sepsis.
translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-25
Marik's Discovery Saves Founder Fonorow's Own Life
With The world poised to change almost over night… Owen Fonorow was reminded that his own rare health condition (adrenal insufficiency) is similar to the condition former US president John F. Kennedy Jr. suffered most of life: Addison's disease or total adrenal failure.
John F Kennedy lacked, and Fonorow lacks, the ability to make sufficient amounts of the adrenal hormone cortisol.
The American public was not aware of JFK's condition. If Kennedy didn't get his cortisol (hydrocortisone is the bioidentical molecule), he'd soon be near death.
Last weekend Owen almost died because of his adrenal insufficiency, apparently aggravated by a defective hernia mesh. According to Fonorow,
Then I remembered the Paul Marik, MD Sepsis cure includes vitamin C – most likely because the cortisol receptors get oxidized.
I REMEMBERED I HAD RESEARCHED AND WRITTEN A PAPER ON THE BIOAVAILABILITY OF VITAMIN C SHOWING ORAL VITAMIN C AS ASCORBIC ACID CAN REACH HIGHER THAN IV/C LEVELS IN THE BLOOD. IT DAWNED ON ME THAT I KNEW HOW TO GIVE MYSELF AN EQUIVALENT TO AN INTRAVENOUS VITAMIN C INFUSION – ORALLY!
This knowledge (to be published in a paper accepted by the Journal of Orthomolecular Medicine) saved my own life last Sunday.