Vitamin C Articles
GULO: The One Thing To Know About Vitamin C
By Owen Fonorow
All humans are born with a genetic defect. Our livers are missing a key enzyme; xl-gulono-§-lactone oxidase that is required to synthesize ascorbic acid from glucose. The loss of a single gene prevents you from making your own vitamin C. The negative mutation of the so-called GULO gene has been well studied in both human and primate genomes. If this negative mutation could be corrected, most people wouldn't need to supplement vitamin C.
As with any inherited malfunction, our inability to produce the GULO enzyme has many negative consequences. Most people are taught to believe that they can obtain enough vitamin C in their foods, consequently they supplement too little. While the food argument generally holds true for most other vitamins, the idea that you can obtain the vitamin C necessary in food is countered by the facts; out of all the species alive today, we are almost alone with a GULO-like genetic defect.
Most living things today make their own vitamin C and do not have to eat it. They do this by converting glucuronic acid (C6H10O7) derived from glucose (C6H12O6) into ascorbic acid (C6H8O6). The well known exceptions that cannot make their own vitamin C are guinea pigs, fruit eating bats, the red vented bulbul bird and some higher primates (e.g. gorillas and we humans).
With a working GULO gene, humans would make their own vitamin C in "fantastic" amounts by today's standards.
Gorillas in captivity are susceptible to the same set of diseases and we share other conditions with these primates that are not common in other species (e.g., cardiovascular disease ). Linus Pauling elucidated in his Unified Theory of Cardiovascular Disease paper, and in a video-taped lecture, that a large consequence of our genetic deficiency is our tendency to develop cardiovascular disease; a primary cause of death. (See: PaulingTherapy.com)
Correcting for the GULO mutation requires much more vitamin C than is commonly recommended by medical and governmental authorities. Animals produce much more vitamin C in their bodies than what we can obtain from the meager dosages often recommended for humans. Adjusted for body weight and under ordinary conditions, animals have been found to produce between 3,000 mg and 13,000 mg of ascorbic acid daily. A goat under stress may produce over 100,000 mg of ascorbic acid daily. As these animals make their own ascorbic acid, the molecule enters the blood stream intact (directly from the liver or kidney).
Ascorbate (another term now used for vitamin C) is volatile and reacts easily with other substances. This means we lose some vitamin C when we eat it during digestion. Scientists have estimated that 50% or more of the vitamin C taken by mouth may not reach the blood stream intact (is not bio-available). The loss increases as the dosage by mouth increases. (Note: The new truly encapsulated liposomal vitamin C increases bio-availability and may even be 100% absorbed at the recommended dosages. See Foundation Approved Liposomal Vitamin C)
Linus Pauling according to a biography did not begin taking vitamin C until his sixth decade of life. At the age when most of us retire, Pauling instead became a champion of vitamin C. Pauling wrote that his daily intake of ascorbic acid was 18,000 mg. Pauling's reasoning behind his dosage is interesting. He tells us during a 1980s video-taped lecture on Vitamin C and Cancer that his personal dosage was based on his body weight and the expected loss of ascorbate taken by mouth.
Pauling knew that on average, mammals of his body weight have evolved to make 9,000 mg of vitamin C throughout a typical day. Pauling experimentally determined that at this dosage, he lost approximately 50% of the vitamin C during digestion. For this reason he doubled the dosage an animal would produce and he consumed 18,000 mg daily in two divided dosages (i.e., 2 dosages of 9,000 mg twice daily). He said this 18 gram daily dosage would account for the loss, and approximate the blood and tissue concentrations of species that make their own ascorbate.
Linus Pauling pointed out that vitamin C has no known toxicity, so there is little risk from this dosage. Pauling lived to the age of 93, and as his last video lecture on heart disease proves (given without notes), his mind at age 92 was still sharp and exceptional.
Take Home MessageWe may be at the onset of creating human life spans longer than 125 years. Linus Pauling anticipated that anti-aging science would discover significant longevity benefits from taking high amounts of vitamin C. He stated this belief in his still authoritative book How To Live Longer and Feel Better. Pauling wrote that although he couldn't prove it at the time, he believed that by taking his recommended high anti-oxidant regimen, especially vitamin C, human beings could extend their period of healthy life, perhaps 20 or 30 years.
As more people become interested in the new anti-aging nutrient science and technologies, including and especially telomerase activation medicine, they may not consider vitamin C all that important. We beg to differ. In our opinion, there is no other nutritional supplement more important for its anti-aging properties. It makes little sense to attempt to extend life while ignoring this easily correctable genetic defect. Any anti-aging and life span extending technology, in our opinion, begins with Vitamin C replacement to account for the damaged GULO gene.
Ebola - Does This Super-Virus Cause a Super-Vitamin C Deficiency?
It may very well be that large Bowel Tolerance dosages of vitamin C against Ebola are too little too late. Instead, if you, like most people, don't have ready access to intravenous vitamin C, you may want to employ the Russel Jaffe, MD, PhD, Vitamin C Calibration/Cleanse protocol. This protocol was designed for heavy metal detoxification, and it should not be discontinued before the flush because any toxins mobilized by vitamin C need to be excreted.
In case of suspected Ebola we recommend the following Jaffe protocol.
- Setup: Determine the largest single dosage that will not
cause diarrhea. (This step must be done ahead of time, i.e. right
now, if you are not a regular vitamin C "mega" doser.) The one-time
dosage is usually 1.5 gram (healthy people) or 3 grams (feeling poorly)
or 6 (up to 12 grams - chronically ill).
Cleanse: Take the one-time maximum dosage every 15 minutes until
the flush, i.e., watery discharge (loose stools don't count.) The
watery flush usually occurs before the two hour mark.
Note: When you are well, you can use Dr. Jaffe's Calibration procedure to help you estimate how much vitamin C you should be taking daily. The optimal daily amount is usually put at 75% of your two-hour calibration.
Figure 3:"Based on ascorbate calibration, it is evident from Figure 3 that 80% of people require at least 10 g of ascorbate (vitamin C) daily for optimum physiological function, and this amount can be as high as 130g/day." - Russell Jaffe, MD, PhDAscorbate Calibration as measure of ReDox, methylation efficiency, and inflammation or repair deficit (PDF). See Appendix I, Page 32 (Originally published in the Townsend Letter for Doctors and Patients.)
- Can Vitamin C Cure Ebola? (Steve Hickey, Hilary Roberts and Damien Downing)
- Cathcart's Bowel Tolerance Paper (PDF)
- Cathcart's Ebola Page
- Levy's Ebola Article
- Foundation's Forum Ebola Virus Discussion
- Russel Jaffe Scientist of the Year (Forum Discussion)
Promise of Liposomal Vitamin C Against Acute Infection
Thomas Levy, MD, JD, has published his clinical observations that highly encapsulated liposomal vitamin C may exceed the effectiveness of intravenous vitamin C clinically by a factor of 10! (gram for gram). The Foundation refers to this effect fighting acute infections as the Levy Amplification Effect.
Some experts disagree, such as Dr. Steven Hickey, PhD, who believes that it is impossible for liposomal vitamin C to be more effective than intravenous vitamin C which is infused directly into the vein. The argument is a matter or reasonableness. However, this argument is not based on evidence from clinical studies, and Hickey may be ignoring an important clinical effect. We have observed the very same effect against infection as we amass reports from users of our our new China-FREE Liposomal Vitamin C.
Daniel Chong: How Vitamin C Can Help You Live a Better Life
Autism: Food for Thought
Do you have a child with Autism, or know someone with Autism or other neurological disorders?If so, This must-see video explains how one mother changed her autistic child's life with diet.
Risk of gout was found to be lower in individuals with higher vitamin C intake. Compared to individuals with a total vitamin C intake of less than 250 mg per day, those with total intakes of 500 - 999 mg per day had a 17 percent reduced risk of gout. For intakes of 1,000 - 1,499 mg and 1,500 mg or more per day, the risk of getting gout was down by 34 and 45 percent, respectively.
The authors of this study also looked at the relationship between amounts of vitamin C ingested in supplement form only and risk of gout. Here again, higher supplemental levels were associated with a reduced risk of gout. Compared to those who did not supplement with vitamin C, those supplementing with 1,000 - 1,499 mg and 1,500 mg or more of vitamin C per day were found to be at 34 and 45 percent reduced risk of gout, respectively.
These results suggest that vitamin C, either from diet or supplements, is associated with a reduced risk of gout.
Furthermore, there were zero deaths in 2007 from any dietary mineral supplement. This means there were no fatalities from calcium, chromium, zinc, colloidal silver, selenium, iron, or multimineral supplements. There was one death from chronic overdose of magnesium hydroxide, commonly known as the laxative/antacid milk of magnesia, and it was inappropriately listed in the "dietary supplement" reporting category. Nutritional supplements do not contain magnesium hydroxide.
Over half of the U.S. population takes daily nutritional supplements. Even if each of those people took only one single tablet daily, that makes 154,000,000 individual doses per day, for a total of over 56 billion doses annually. Since many persons take more than just one vitamin or mineral tablet, the numbers are considerably higher, and the safety of nutritional supplements is all the more remarkable.
Asc-2-O-phosphate (Asc2P), which concurrently achieved both extension of cellular life-span and prevention of cell size enlargement indicative of cellular senescence.
Thus, age-dependent telomere-shortening can be decelerated by suppression of intracellular oxidative stress and/or by telomerase retention, both of which are achieved by enriched Asc(in) but not by extracellular Asc overwhelmingly."
They concluded there are 8 million Americans at least 55 years old thought to be at high risk for the problem. If all the people at risk took the supplements used in the earlier study, more than 300,000 of them would avoid advanced macular degeneration and any associated vision loss during the next five years, the study said."
There's no question that vitamin C is a big gun in the anti-cancer arsenal!
This would be a good test to see if a mole is cancerous or not. Just rub on the C solution and if it crusts up and falls off it was, if nothing happens then it's probably not cancer. We know from Dr. Riordan's research that C is toxic to melanoma in cell culture." (Read more)
Lyme Spirochete Found in the Brain of MS Patients
The causative organism of Lyme disease, Borrelia burgdorferi, has been found in the brains of many victims of multiple sclerosis (MS).
Listing 5: Lyme Disease Linked to Four Major Diseases Multiple Sclerosis, Alzheimer's, Systemic Scleroderma and Arthritis
ALZHEIMER'S: The spirochete Borrelia burgdorferi (Bb) has been found in the brain of many Alzheimer patients. Also in the brain, antigens and genes of Bb have been co-localized with beta-amyloid deposits.
MULTIPLE SCLEROSIS: The spirochete Borrelia burgdorferi has been found in the brain of many multiple sclerosis (MS) patients along with amyloid deposits. MS has been linked to Lyme disease both seasonally and by location.
SYSTEMIC SCLERODERMA: The spirochete Borrelia burgdorferi (Bb) has been found in the blood in systemic scleroderma. Treatment with antibiotics effective against Bb returned the skin to normal.
LYME-INDUCED ARTHRITIS: Only certain strains of Bb are capable of causing the symptoms of arthritis.
Our Readers Have Suggested Alternate Forms of Unrefined Salt
- Himalayan salt ("unrefined salt that comes from in the Himalayan Mountains")
- Real salt (May go through fewer production processes than Celtic.)
- Celtic (Recommended by Brownstein and shown to be clinically effective in his practice)
Refined Versus Unrefined SaltDr. David Brownstein reports that his clinical experience, and literature research, indicates that refined refined salt (such as ordinary table salt) and unrefined salt are different. He considers ordinary, highly refined (e.g. table) salt to be poisonous. He recommends unrefined Celtic Sea Salt (celticseasalt.com) and compares it to a health food, providing more than 80 minerals.
"The article's overgeneralization has resulted in news headlines warning doctors and patients to avoid the use of all dietary supplements during cancer therapy. If true, a warning should also be issued for nutrient-rich foods like fruits, vegetables and nuts; especially if concentrated into juices. Since there is conflicting data and these nutrients are so essential, I do not support either warning." - Neil E. Levin
Co-enzyme Q 10 300 - 360mg (the oil of the engine - moves electrons from one molecule to another)
L-carnitine 2,000 - 3,000mg (the oil of the engine - moves ATP and ADP across mito membranes)
D-ribose 15grams (raw material to make new ATP)
Magnesium 400 - 800mg (the spark plugs - fires up many enzyme reactions)
Incidentally this helps explain why some CFS sufferers have such problems with drug medication and indeed this may help to point towards treatment. All my CFS patients feel much worse on statin (cholesterol-lowering) drugs because these stop the body from making its own Co Q 10. Beta blockers, tricyclic antidepressants and phenothiazines also block Co Q 10 synthesis.
If Cuban medicine were so good, they wouldn't have had that episode of blindness about ten years ago where fifteen or twenty thousand Cubans - it might even be as many as thirty thousand - went blind because of a vitamin deficiency. There wasn't a single Cuban doctor who could diagnose it properly. It took a charitable team of American doctors that were allowed to go in there to diagnose it. It was such a simple thing."
Our Rebuttal to a Nov 2005 Story in the Malaysian New Straits Times Online
"[Our] study, which explored the effect of statins and vitamin C on transcriptional expression of gene coding for this nuclear receptor/transcription factor family within mononuclear cells, revealed for the first time that both mevastatin and vitamin C have common action in that they significantly downregulate the expression of PPAR (alpha, gamma) genes and upregulate LXR-alpha gene expression as compared to the control."
- Male mice showed a 40% increase in median lifespan (to 85 ± 4 weeks from 61 ± 4).
- 17% increase in maximal lifespan (to 136 weeks from 116 weeks).
- Increases in the ability to perform tests measuring neuromuscular performance (high-wire tightrope) and cognitive exploratory activity (T-maze); the increases on both tests ranged 9%-24% at 52 weeks, and 28%-45% at 78 weeks of age.
- Brain alpha-tocopherol content increased 2.5-fold in male mice taking vitamin E.
- Vitamin E supplementation offset various measures of mitochondrial function loss in a range of 37%-66% at the 52- and 78-week test points.
- All results were significant to a greater than 99% confidence level.
God bless - Paul L.
Study Finds Vitamin C Can Kill Drug-Resistant TB
Dr. William Jacobs, Jr. has determined that vitamin C kills drug-resistant tuberculosis (TB) bacteria in laboratory culture. The paper was published online May 21, 2013 in Nature Communications. Dr. Jacobs is professor of microbiology & immunology and of genetics at Albert Einstein College of Medicine. Dr. Jacobs is also a Howard Hughes Medical Institute investigator. See accompanying release: Study Finds Vitamin C Can Kill Drug-Resistant TB and the youtube video.
Linus Pauling Institute Fails Linus Pauling.
The truth about vitamin C: Vitamin C: Myths And Reality Outside The Research Laboratory By Bill Sardi.
Vitamin C Linked to Reduced Stroke Risk Finally reported by a mainstream media.
In an odd coincidence, only 3 days prior to the release of the real Mayo Clinic study about carnitine, a story with the opposite information about carnitine was released, per this article in the Huffington post L-Carnitine, Nutrient In Red Meat, Linked With Heart Disease
The first story was discussed by our forum at this topic
Note: Vitamin C Foundation Approved® Vitamin C is NOT Made in China
Silvia Maggini at Bayer Consumer Care Ltd in Basel, Switzerland and colleagues presented data from two preliminary, double-blind, randomized, placebo-controlled trials in which patients with the common cold were given a combination of 1000 mg vitamin C and 10 mg zinc for five days.
In both trials, the vitamin C plus zinc supplement nonsignificantly reduced rhinorrhoea duration by 9 to 27 percent. In an analysis of combined data from the two trials of 94 subjects, the vitamin C plus zinc supplement reduced rhinorrhoea over a 5-day treatment more effectively than placebo.
While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control. "We had tested this theory on research models, but this is the first time anyone has shown the therapy's effectiveness in people," said Michael Ihnat, Ph.D., principal investigator and a pharmacologist at the OU College of Medicine Department of Cell Biology.
Research published in the Journal of Clinical Investigation found that a specific protein called Slc23a1 may regulate the ability of a newborn's kidneys to absorb the nutrient. Having adequate levels of vitamin C during pregnancy can ensure that a number of bodily systems run smoothly.
Read more Vitamin C News
Food for Thought
Do you have a child with Autism, or know someone with Autism or other neurological disorders?If so, this must-see video explains how one mother changed her autistic child's life with diet.
(VCF COUPON CODE: LE59P1 at primalpanacea.com)
Dr. Chris Shade's (Quicksilver Scientific) Mercury Detox Lecture at the Diane Meyers 2009 Mercury Symposium as (PDF) or larger (Powerpoint).
Mercury Poisoning: IV/C Case Report (pdf) This article published in the July 2011 Townsend Letter supports our contention that Cathcart's method of mixing sodium ascorbate is superior to the commercial IV/C products, esp. for brain related issues; e.g., higher pH, gentler on veins, no preservatives, more stable and thus more powerful, etc. Forum Mercury Case Archive
CONCLUSION: Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.
- Intravenous Vitamin C Saves New Zealand Man with H1N1 Flu Damaged Lung (Story we posted last January)
- Vitamin C: 'Miracle Nutrient' That Cured Man on the Brink of Death...
- Dr. Thomas Levy Lectures at 'Vitamin C Can Cure' Coalition in New Zealand (Video)
- Segment 3: Levy's Discussion of Vitamin C Toxicity and Kidney Stones (Video)
Huffington Post just published Women Who Take Vitamin Supplements May Have Increased Death Risk, at precisely the moment that the pharmaceutical industry is in health attack mode to limit access to nutritional supplements in the US. How coincidental!
The AMA, which is heavily funded by Pharma, put out a study purporting to show that vitamins are a threat to people's lives..."
In a time of budget cutting and deficits, the FDA somehow has the capacity to go after one of the safest substances known!
FDA said these statements about the RapidMelts Vitamin C products are intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in violation of section 201(g)(1)(B) of the Act (21 U.S.C. § 321(g)(1)(B)). Also, the statements say the products are intended to affect the structure or function of the body of man in violation of section 201(g)(1)(C) of the Act (21 U.S.C. § 321(g)(1)(C))
No Deaths from Vitamins - None at All in 27 Years Orthomolecular News Service
- Jonathan Barnet@resistanceisfruitful.com
The Vitamin A and Vitamin D Controversy
Since vitamin A is required as a signaling partner with vitamin D, vitamin D will increase the turnover of vitamin A. If vitamin A is provided in excess, the results are generally beneficial. Excess vitamin A is stored in the liver. However, when the liver's storage capacity is exceeded, the overload of vitamin A causes the cells to burst, damaging the liver and releasing storage forms of vitamin A into the systemic circulation that do not belong there. By increasing the utilization of vitamin A, vitamin D can help prevent vitamin A toxicity.
If vitamin A is in short supply, on the other hand, the results can be detrimental. By .stealing. all of the vitamin A needed to use for vitamin Dspecific functions, the body will not have enough vitamin A left to support the many other functions for which it is needed.this may partially explain the toxic effects of excess vitamin D.
Is patent 5,336,499 the general antidote for all bio warfare weapons? i.e. is it the cure for Lyme?
United States Patent 5,336,499 Antelman August 9, 1994 Molecular crystal device for pharmaceuticals Abstract A novel molecular scale device is described which is bactericidal, fungicidal, viricidal and algicidal. The anti-pathogenic properties of the device are attributed to electron activity indigenous to diamagnetic semiconducting crystals of tetrasilver tetroxide (Ag.sub.4 O.sub.4) which contains two monovalent and two trivalent silver ions in each molecular crystal. When the crystals are activated with an oxidizing agent, they release electrons equivalent to 6.4.times.10. sup.-19 watts per molecule which in effect electrocute pathogens. A multitude of these devices are effective at such low concentrations as 0.3 PPM used as preservatives in a variety of formulations ranging from cosmetics to pharmaceuticals. Indeed, they are intended as active ingredients for pharmaceuticals formulated to destroy such pathogens as Staphylococcus aureus, and epidermidis, the latter of which it completely destroys in a nutrient broth culture of about 1 million organisms at 0.6 PPM, or Candida albercans, the vaginal yeast infection at 2.5 PPM, and the AIDS virus at 18 PPM. Inventors: Antelman; Marvin S. (Rehovot, IL) Assignee: Antelman Technologies, Ltd. (Providence, RI) Appl. No.: 07/971,933 Filed: November 5, 1992
Foundation Does Not Sell Vitamin C
Quali-C® is a registered trademark of DSM Nutritional Products.
True-Liposomes™ is a trademark of The Vitamin C Foundation.
China-FREE™ is a trademark of Inteligent*Vitamin*C Inc.
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Cathcart's IVC preparation and bowel tolerance videos are now available on youtube.
Owen's Radio Interviews on the Jeff Rense Show Listen to show archive (Aug 14, 2008) The second hour with Pauling Therapy survivors Carol Smith and Carol 2 from Hawaii...
New: John Beard's 1911 book THE ENZYME TREATMENT OF CANCER AND ITS SCIENTIFIC BASIS Online Enzyme Treatment of cancer. Thanks to Edward Monson for scanning/OCRing this very rare book.
Updates: Stone's Book (Healing Factor) and Cathcart Videos Online Healing Factor. Many thanks to John Jenkins for scanning a providing the missing figures and diagrams.
Vitamin C Foundation